Composition:

Thiamine HCl

Indications:

• Thiamin deficiencies related to increased lactic acid concentration in muscles and malnutrition, fatique, muscle weakness, loss of appetite and increased heart rate, nervous symptoms and overexcitation.
• Treatment of bracken poisoning in horses.

Principles of action:

Thiamine is important in the breakdown of pyruvic acid, a waste product in hard working muscles, along with lactic acid. In any situation where carbohydrates are the major energy source, or when glucose is added to the diet, thiamine requirement is increased significantly.

Thiamine combines with adenosine triphosphate (ATP) to form thiamine pyrophosphate, also known as cocarboxylase, a coenzyme. Its role in carbohydrate metabolism is the decarboxylation of pyruvic acid in the blood and a-ketoacids to acetaldehyde and carbondioxide. Increased levels of pyruvic acid in the blood indicate Vitamin B1 deficiency.